Washington University of St. Louis Surgery in St. Louis, Missouri

Post Doc Instructions

Please do not submit an application to this posting. To apply for this postdoctoral research opportunity, follow the directions below in “Applicant Special Instructions”.

Job Type/Schedule

This position is full-time and works approximately 40 hours per week.

Department Name/Job Location

This position is in the Department of Surgery, Division of Gynecologic Oncology. This position is for the Medical School Campus.

Essential Functions


The Spitzer Lab is looking for an enthusiastic scientist who is passionate about creating the next generation of targeted protein-based immunotherapeutics. Our research is focused on the development and clinical translation of targeted TRAIL-based cancer biologics (REFs). Current projects in the lab center on the development and engineering of (scFv) antibody fusion proteins being used in single-agents trials as well as in combination with other cancer-targeted biologics/small molecules. The created compounds will be tested in vitro and in preclinical mouse models of ovarian and/or pancreatic cancer and lead candidates will be optimized for clinical translation. The ideal candidate should be highly experienced in scFv antibody/protein drug discovery as well as engineering and share our vision for the development of next-generation immunoproteins.


  1. Develop and execute strategies to engineer proteins that strongly and specifically bind a desired target using molecular biology and high-throughput screening techniques.
  2. Utilize protein purification techniques and analytical methods to characterize proteins of interest.
  3. Participate in grant/manuscript/presentation preparation.
  4. Advance research projects through synergistic interactions with both other lab members and collaborators.

Required Qualifications

Prior experience in molecular biology is essential. Additional experience in basic functions of the immune system will be an asset. Other qualifications include a Ph.D. and/or M.D. degree and a strong publication track record.

Preferred Qualifications

  • First author publication(s) in protein engineering or relevant field; broad knowledge of protein engineering strategies.
  • Track-record of productive biochemical lab experience including cloning, protein expression (bacterial and/or mammalian), protein purification, and/or biophysical characterization.
  • Experience with phage display, yeast display or similar molecular evolution-based approaches.
  • Experience with in vivo mouse studies.
  • Enjoy taking calculated risks and operating with urgency.
  • Additional experience/knowledge in (cancer) immunology and immune system will be an asset.

Salary Range

Base pay commensurate with experience.


This position is eligible for full-time benefits. Please visit our website at http://hr.wustl.edu to view a summary of benefits.

Applicant Special Instructions

Please email a cover letter, CV, and a list of three references to Dr. Dirk Spitzer at spitzerd@wudosis.wustl.edu.

EOE Statement

Washington University is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, age, sex, sexual orientation, gender identity or expression, national origin, genetic information, disability, or protected veteran status.

Job Title: Postdoctoral Research Associate - Surgery - 41186

Job ID: 41186

Location: Medical School

Full/Part Time: Full-Time

Regular/Temporary: Regular