Patheon Supervising Principal Scientist, Cell Culture in St. Louis, Missouri

Job Descriptions:

Patheon is one of the world’s largest contract manufacturing and development organizations (CDMOs) offering end-to-end, fully integrated services for both drug substances and drug products. We facilitate both large and small pharma companies’ ability to deliver life changing therapies to their customers.

Our biologics division is on a strong growth trajectory continuously investing in our global network of facilities to ensure our clients have access to cutting-edge technologies, innovative solutions and product delivered with world class quality. Patheon Biologics is currently a network of four manufacturing sites offering early phase process development in Princeton, NJ, late phase process development and commercial and clinical manufacturing in St. Louis, MO and clinical and commercial manufacturing in Brisbane, Australia and Groningen, The Netherlands.

Our cell culture development team in St. Louis MO is expanding and we’re looking for a talented and experienced Principal Scientist to join our upstream group. This position will be responsible for leading projects such as media/feed optimization, bioreactor process development and process characterization. A person in this role is expected to lead projects, troubleshoot technical challenges, apply new technologies and interact frequently with customers. Additionally, this person is expected to mentor the activities of junior staff and may have direct reports depending on level.

This position requires excellent interpersonal and presentation skills with demonstrated ability to present effectively in client meetings and reports. The candidate should be self- sufficient in planning and executing daily activities and able to troubleshoot technical challenges and apply innovative technology to improve efficiency.

As a Principal Scientist, you will be expected to:

  • Act as a lead upstream scientist on multiple programs having project oversight and direct and/or indirect report management responsibilities.

  • Plan project scope, timing and resource requirements.

  • Design and develop mammalian cell culture processes to support the production and manufacturing of recombinant proteins (including mAbs) with activities including:

  • Clone and media/feed screening using AMBR technology

  • Bioreactor culture development including fed-batch, perfusion and XD® technologies (2 to 50L scale) with both glass and single use cell culture technologies.

  • Design experimental plans based on the defined deliverables, planning the activities to meet the project timelines by working closely with project managers.

  • Lead the transfer of developed upstream processes to the global manufacturing network including documentation and technical know-how.

  • Write, revise and approve process development reports and technology transfer protocols.

  • Attend project-team meetings. Present and discuss the data and project progress at those meetings.

  • Stay current with relevant technologies and be able to identify and justify new equipment needs.

Required Experience:

  • For our Principal Scientist, candidates are expected to have a Ph.D. degree in a relevant field with at least 5 years of industry experience or equivalent. Relevant disciplines and areas of experience include chemical/biomolecular engineering, biology, cell biology, biochemistry, or equivalent science and/or engineering discipline.

Other ideal Skills and Abilities

  • Ability to work in a fast paced environment

  • Excellent organization and planning skills

  • Capable of working within a team or independently with minimal direction

  • Must have strong communication skills and interpersonal skills.

  • Experience using design of experiments (DoE) software (i.e. MiniTab, JMP) preferred.

  • Fed-batch and/or perfusion bioreactor experience preferred.

  • For those with bioreactor culture development experience, it is preferred candidates have expertise with Sartorius (including MFCS) and/or Finesse bioreactor control systems

  • Understanding of cGMP strongly preferred

  • Experienced in designing and optimizing cell culture processes with manufacturing in mind

  • Ability to work with computer controlled systems and proficient with Microsoft Word, Excel, and PowerPoint required

  • Experience with Microsoft Project preferred.

Keyword: bioreactor, Fed-batch bioreactor, perfusion bioreactor

From: Patheon