Washington University of St. Louis Postdoctoral Research Associate - Pediatrics Rheumatology - 42326 in St. Louis, Missouri

Post Doc Instructions

Please do not submit an application to this posting. To apply for this postdoctoral research opportunity, follow the directions below in “Applicant Special Instructions”.

Job Type/Schedule

This position is full-time and works approximately 40 hours per week.

Department Name/Job Location

This position is in the Department of Pediatrics Rheumatology. This position is for the Medical School Campus.

Essential Functions

A postdoctoral fellow position is available in the laboratory of Anthony French to study dysregulated innate immunity in pediatric patients with immunodeficiencies and autoimmunity. The French laboratory is particularly interested in delineating innate immune defects in patients with unusually severe and/or recurrent herpesvirus infections and innate immune signaling defects in pediatric patients with autoimmune disorders such as juvenile dermatomyositis (JDM) and systemic juvenile idiopathic arthritis (sJIA).

Using cutting edge, high dimensional techniques including mass cytometry (CyTOF), RNA-seq, and whole exome sequencing, the laboratory has a number of patients at different stages of evaluation. The laboratory recently published a manuscript (Throm et al., JCI Insight 2018) describing defects in phospholipase C-gamma 2 (PLCG2) signaling in NK cells in 17 treatment naïve JDM patients compared to 17 healthy pediatric controls which manifests in decreased NK cell calcium flux. This position would build on ongoing studies in the laboratory to understand the mechanistic underpinnings and functional implications of the dysregulation of PLCG2 phosphorylation in these JDM patients, with the goal of developing strategies to mitigate the impact of this innate immune signaling defect in JDM patients.

Required Qualifications

  • PhD, MD, or equivalent terminal doctoral degree.
  • Candidates should have experience in immunology as well as cellular and molecular biology.
  • The applicant should possess strong written and oral communication skills as well as demonstrated ability to implement laboratory protocols, independently conduct and interpret research experiments, and document research findings.
  • The candidate should be highly motivated, creative, and be able to work both independently and within a team.

Preferred Qualifications

  • Experience with tissue culture, flow cytometry, and cellular functional assays would be beneficial.
  • Familiarity with basic statistical analysis and R is desirable.

Salary Range

Base pay commensurate with experience.

Benefits

This position is eligible for full-time benefits. Please visit our website at http://hr.wustl.edu to view a summary of benefits.

Applicant Special Instructions

Applicants should send a cover letter including a description of their career goals, a paragraph on their prior research experience, curriculum vitae, and the names and contact information for 3 references to Dr. Anthony French (french_a@wustl.edu).

Laboratory environment with potential exposure to biological and chemical hazards including human biospecimens (e.g., blood).

Information on being a postdoc at Washington University in St. Louis can be found at postdoc.wustl.edu/prospective-postdocs.

EOE Statement

Washington University is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, age, sex, sexual orientation, gender identity or expression, national origin, genetic information, disability, or protected veteran status.

Job Title: Postdoctoral Research Associate - Pediatrics Rheumatology - 42326

Job ID: 42326

Location: Medical School

Full/Part Time: Full-Time

Regular/Temporary: Regular