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Washington University of St. Louis Postdoctoral Research Associate - Nephrology - 47733 in St. Louis, Missouri

Post Doc Instructions

Please do not submit an application to this posting. To apply for this postdoctoral research opportunity, follow the directions below in “Applicant Special Instructions”.

Department Name/Job Location

This position is in the Department of Internal Medicine, Nephrology Division. This position is for the Medical School Campus.

Essential Functions

POSITION SUMMARY:

An opportunity is immediately available for a Postdoctoral Research Associate at the Washington University Division of Nephrology. Endoplasmic reticulum (ER) dysfunction and protein misfolding disease is an emerging field. The overall goals of our research are to delineate the molecular mechanisms underlying ER stress-mediated kidney diseases, including nephrotic syndrome (NS), Alport syndrome, autosomal dominant tubulointerstitial kidney disease (ADTKD), acute ischemic kidney injury, and other acquired forms of ER disease, to develop ER stress biomarkers in human patients, and to identify ER stress modulators. The posted position will focus on mechanism investigation, novel signaling pathway identification and therapeutic intervention in the area of podocyte ER stress and ER calcium dyshomeostasis (Proc Natl Acad Sci 116: 14154-14163, 2019; JCI Insight 2(23): e92896 2017; J Am Soc Nephrol 27: 2974-2982 2016; J Am Soc Nephrol 24: 1223-1233 2013; one issued patent related to the discovery of two ER stress biomarkers). We are using cutting-edge research approaches, including stably transfected or knock-down cells, molecular and cell biology, biochemistry, inducible transgenic, conditional knock-out and CRISPR generated knock-in mouse models, human iPSCs derived from patients, and state-of-the-art in vitro & in vivo imaging techniques. We also have access to multiple kidney disease consortiums to acquire their genomic data, gene expression, histology from kidney biopsies, and urine samples. The PI’s research has been funded by multiple grants from NIH, Department of Defense etc. and industry. The lab environment is highly supportive.

Required Qualifications

  • A PhD or MD/PhD degree in biochemistry, molecular biology, molecular genetics or other related fields.
  • A strong background in molecular biology or biochemistry.

Preferred Qualifications

Experience with ER or podocyte biology, mouse genetic models, or kidney-related research is highly desired.

Salary Range

Base pay commensurate with experience.

Pre-Employment Screening

All external candidates receiving an offer for employment will be required to submit to pre-employment screening for this position. Current employees applying for a new position within the university may be subject to this requirement. The screenings will include a criminal background check and, as applicable for the position, other background checks, drug screen, employment and education or licensure/certification verification, physical examination, certain vaccinations and/or governmental registry checks. All offers are contingent upon successful completion of required screening.

Department Summary

The Washington University Division of Nephrology (https://renal.wustl.edu) is a top research-focused academic division. The research environment is outstanding.

Benefits

This position is eligible for full-time benefits. Please click the following link to view a summary of benefits: https://hr.wustl.edu/benefits/.

Applicant Special Instructions

Interested candidates should email a CV, cover letter and the names of three references to:

Y. Maggie Chen, MD, PhD

Associate Professor of Medicine

Director, Nephrotic Syndrome Clinic Division of Nephrology Washington University School of Medicine Box 8126 660 S. Euclid Avenue St. Louis, MO 63110

Email: ychen@dom.wustl.edu

EOE Statement

Washington University is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, age, sex, sexual orientation, gender identity or expression, national origin, genetic information, disability, or protected veteran status.

Job Title: Postdoctoral Research Associate - Nephrology - 47733

Job ID: 47733

Location: Medical School

Regular/Temporary: Regular

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