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Washington University of St. Louis Postdoctoral Research Associate - Genetics - 50733 in St. Louis, Missouri

Post Doc Instructions Please do not submit an application to this posting. To apply for this postdoctoral research opportunity, follow the directions below in “Applicant Special Instructions”. Department Name/Job Location This position is in the Department of Genetics. This position is for the Medical School Campus. Essential Functions Postdoctoral positions in Precision Neurology focused on analyzing disease-associated genetic variants using quantitative imaging, metabolomics and single cell genomics. The laboratories of Drs. Jeff Milbrandt and Rob Mitra invite highly motivated candidates to apply for positions as joint postdoctoral fellows in the Department of Genetics and McDonnell Genome Institute at Washington University in St. Louis. These fellows will develop research programs in Personalized Medicine aimed at revealing the pathogenic mechanisms of disease-associated variants via monitoring phenotypic changes of genetically perturbed iPSC-derived neurons and glia. Our collaborative, multidisciplinary group studies the mechanistic basis of genetic abnormalities that result in neurodevelopmental, neuropsychiatric, or neurodegenerative disorders, with particular emphasis on the role of mitochondrial dysfunction and metabolic deficits in disease progression. To address these questions, we use a novel multi-omics approach that integrates high-throughput imaging and machine learning methods with CRISPR/Cas9 screens and saturation mutagenesis to answer central questions about the pathophysiology that results from genetic mutations in mitochondrial proteins, chromatin regulators, and metabolic enzymes. We interpret our experiments in the context of curated clinical phenotypes and validate key findings using banked patient samples. Multiple full-time positions are available immediately and are funded for up to three years, with the possibility of extension. Information on being a postdoc at Washington University in St. Louis can be found at postdoc.wustl.edu/prospective-postdocs. Washington University School of Medicine (WUSM) has a rich history of success in research, education and patient care, earning it a reputation as one of the premier medical schools in the world. The University is internationally known for studies in genetics and neuroscience. Required Qualifications * Ph.D. or MD/Ph.D. in biological sciences or related fields. * Experience in molecular biology or genomics. * Good communication skills. * Must be able to visit St. Louis for potential interviews. Preferred Qualifications Programming skills (Python and R). Salary Range Base pay commensurate with experience. Pre-Employment Screening All external candidates receiving an offer for employment will be required to submit to pre-employment screening for this position. Current employees applying for a new position within the university may be subject to this requirement. The screenings will include a criminal background check and, as applicable for the position, other background checks, drug screen, employment and education or licensure/certification verification, physical examination, certain vaccinations and/or governmental registry checks. All offers are contingent upon successful completion of required screening. Benefits This position is eligible for full-time benefits. Please click the following link to view a summary of benefits: https://hr.wustl.edu/benefits/. Applicant Special Instructions To apply for this position, applicants should email a single PDF file consisting of a letter of interest and CV, and should arrange for three letters of reference to be sent to Drs. Jeff Milbrandt and Rob Mitra at MorphNSort@genetics.wustl.edu. EOE Statement Washington University is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, age, sex, sexual orientation, gender identity or expression, national origin, genetic information, disability, or protected veteran status. Job Title: Postdoctoral Research Associate - Genetics - 50733 Job ID: 50733 Location: Medical School Full/Part Time: Full-Time Regular/Temporary: Regular