Washington University of St. Louis Postdoctoral Research Associate - Endocrine/Metabolism - 42057 in St. Louis, Missouri

Post Doc Instructions

Please do not submit an application to this posting. To apply for this postdoctoral research opportunity, follow the directions below in “Applicant Special Instructions”

Job Type/Schedule

This position is full-time and works approximately 40 hours per week.

Department Name/Job Location

This position is in the Department of Internal Medicine, Division of Endocrinology, Metabolism and Lipid Research. This position is for the Medical School Campus.

Essential Functions

POSITION SUMMARY:

A postdoctoral position is available in the laboratory of Dr. Carlos Bernal-Mizrachi in the Division of Endocrinology, Metabolism and Lipid Research at Washington University School of Medicine. Work from the laboratory has focused on mechanisms by which vitamin D modulates immune cell function and on understanding how the inflammatory milieu contributes to the development of metabolic syndrome. Studies are conducted in mouse models of insulin resistance and cardiovascular complications (diet-induced obesity and multiple genetically modified lines of mice) and in patients with diabetes. Our clinical and preclinical results have shown that regulation of ER stress by vitamin D exerts a pivotal role in monocyte recruitment, macrophage phenotype, and macrophage cholesterol metabolism, all of which are critical components of the vascular remodeling seen in diabetic vascular disease. Additional studies showed that macrophage-specific deletion of the vitamin D receptor increases susceptibility to insulin resistance, atherosclerosis, and hypertension, postulating that regulation of macrophage phenotype by vitamin D is essential in the development of cardiometabolic disease. This position will provide an opportunity to utilize biochemical, molecular, genetic, and immunological and techniques in both animals and humans and to prepare the candidate for a successful career in the field of immunology and metabolism.

ONGOING STUDIES:

Translational:

  • Developmental immune origins of insulin resistance and metabolic syndrome.
  • The effect vitamin D during pregnancy on epigenetic changes in macrophages.
  • The role of immune modulation and microRNAs in the development of metabolic syndrome.
  • Determine the molecular mechanism by which macrophages induce hypertension and atherosclerosis in mice models with insulin resistance and patients with type 2 diabetes and human.
  • Assessing the effects of plasma glucose levels on macrophage cholesterol metabolism in mice and in patients with type 2 diabetes.

Clinical Trials:

  • Randomized control trial evaluating the effects of vitamin D in blood pressure control in patients with type 2 diabetes.
  • Randomized control trial evaluating the effects of vitamin D supplementation of cardiovascular progression in patients with type 2 diabetes.
  • Maternal Vitamin D supplementation effects on offspring inflammation and insulin resistance.

For more information, visit: https://endo.wustl.edu/.

Required Qualifications

PhD degree in glucose or lipid metabolism or immunology.

Preferred Qualifications

  • Willingness to conduct research using mouse models.
  • Strong written and oral communication skills are essential, as evidenced by high-quality international peer-reviewed journals.
  • Ability to work independently and communicate with laboratory staff and investigators.

Salary Range

Base pay is commensurate with experience.

Benefits

This position is eligible for full-time benefits. Please visit our website at http://hr.wustl.edu to view a summary of benefits.

Applicant Special Instructions

To apply, please e-mail a cover letter, CV, and two letters of recommendation and the names and contact information for three references to Dr. Bernal-Mizrachi at cbernal@wustl.edu.

EOE Statement

Washington University is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, age, sex, sexual orientation, gender identity or expression, national origin, genetic information, disability, or protected veteran status.

Job Title: Postdoctoral Research Associate - Endocrine/Metabolism - 42057

Job ID: 42057

Location: Medical School

Full/Part Time: Full-Time

Regular/Temporary: Regular