Washington University of St. Louis Pathology/Immunology in St. Louis, Missouri

Post Doc Instructions

Please do not submit an application to this posting. To apply for this postdoctoral research opportunity, follow the directions below in “Applicant Special Instructions”.

Job Type/Schedule

This position is full-time and works approximately 40 hours per week.

Department Name/Job Location

This position is in the Department of Pathology/Immunology, Division of Immunobiology. This position is for the Medical School Campus.

Essential Functions

POSITION SUMMARY:

A postdoctoral position is immediately available to study molecular mechanisms that regulate hematopoietic and vascular development and regeneration. My lab has expertise on hematopoietic, vascular and stem cell biology as well as stem cell applications and has made significant contributions to the understanding of how hematopoietic and vascular systems are established during embryogenesis. We utilize an in vitro differentiation model of embryonic stem (ES) cells and early mouse embryos to address self-renewal, lineage commitment, and differentiation of the hematopoietic and vascular systems. We are currently focusing on several transcription factors that control commitment from mesoderm to FLK1 expressing mesoderm and from the FLK1 expressing mesoderm to hematopoietic and endothelial cells. Our current projects include 1) transcriptional control of hematopoietic and vascular cell lineage development, 2) directed differentiation and application of hematopoietic and vascular progenitors from stem cells, 3) hematopoietic stem cell biology, 4) hematopoietic and vascular repair and regeneration mechanisms, 5) tumor angiogenesis, and 6) tumor endothelial cell targeted gene delivery.

Recent publications:

Lee, D., Park, C., Lee, H., Lugus, J.J., Kim, S.H., Arentson, E., Chung, Y.S., Gomez, G., Kyba, M., Lin, S., Janknecht, R., Lim, D.S. and Choi, K. 2008. ER71 acts downstream of BMP, Notch and Wnt signaling in blood and vessel progenitor specification. Cell Stem Cell 2:497-507.

Oduro, K. A., Liu, F., Kim, C.K., Lubman, O., Fremont, D.H., Mills, J. C. and Choi, K. 2012. Myeloid skewing in murine autoimmune arthritis occurs in hematopoietic stem and primitive progenitor cells. Blood 120:2203-2213.

Liu, F., Bhang, S. H., Arentson, E., Sawada, A., Kim, C., Kang, I., Yu, J., Sakurai, N., Kim, S., Yoo, J.W., Kim, P., Pahng, S. H., Xia, Y., Solnica-Krezel, L. and Choi, K. 2013. Enhanced Hemangioblast Generation and Improved Vascular Repair and Regeneration from Embryonic Stem cells by Defined Transcription Factors. Stem Cell Reports 1:166-182.

Liu, F., Li, D., Yu, L., Kang, I., Cha, M., Watson, D.K., Park, C., Wang, T. and Choi, K. 2015. Induction of hematopoietic and endothelial cell program orchestrated by ETS transcription factor ER71/ETV2. EMBO Reports 16 (5):654-669.

Park, C., Lee, T., Bhang, S.H., Liu, F., Nakamura, R., Oladipupo, S.S., Pitha-Rowe, I., Capoccia, B., Choi, H.S., Kim, T.M., Urao, N., Ushio-Fukai, M., Lee, D.J., Miyoshi, H., Kim, B., Lim, D.S., Apte, R.S., Ornitz, D.M and Choi, K. 2016. Injury mediated vascular regeneration requires endothelial ER71/ETV2. ATVB. 36:86-96.

Xu, C., Lee, T., Sakurai, N., Krchma, K., Liu, F., Li, D., Wang, T. and Choi, K. 2017. ETV2/ER71 regulates hematopoietic regeneration through hematopoietic stem cell proliferation. J. Exp. Med. 214(6):1643-1653.

Zhao, H. and Choi, K. 2017. A CRISPR screen identifies genes controlling Etv2 threshold expression in hemangiogenic fate commitment. Nature Communications 8(1):541. doi: 10.1038/s41467-017-00667-5.

Required Qualifications

Interested applicants should have a PhD and/or MD degree.

Preferred Qualifications

  • Strong background in molecular biology, cell biology, or mouse genetics.
  • Strong publication record.
  • Demonstrated ability to implement laboratory procedures, conduct research and records findings.

Salary Range

Base pay commensurate with experience.

Benefits

This position is eligible for full-time benefits. Please visit our website at http://hr.wustl.edu to view a summary of benefits.

Applicant Special Instructions

Please send a cover letter, brief description of research experience and interests, curriculum vitae and contact information for three references to:

Kyunghee Choi, Ph.D.

Washington University School of Medicine Department of Pathology

660 S. Euclid Ave, Campus Box 8118

St. Louis, MO 63110

Phone: 314-362-8716

email: kchoi@wustl.edu

Works in a laboratory environment with potential exposure to blood and chemical hazards.

EOE Statement

Washington University is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, age, sex, sexual orientation, gender identity or expression, national origin, genetic information, disability, or protected veteran status.

Job Title: Postdoctoral Research Associate - Pathology/Immunology - Immunobiology - 41583

Job ID: 41583

Location: Medical School

Full/Part Time: Full-Time

Regular/Temporary: Regular