Washington University of St. Louis Nephrology in St. Louis, Missouri

Post Doc Instructions

Please do not submit an application to this posting. To apply for this postdoctoral research opportunity, follow the directions below in “Applicant Special Instructions”.

Job Type/Schedule

This position is full-time and works approximately 40 hours per week.

Department Name/Job Location

This position is in the Department of Internal Medicine, Nephrology Division. This position is for the Medical School Campus.

Essential Functions

A postdoctoral position is available in the laboratory of Dr. Michael Rauchman in the Division of Nephrology at Washington University School of Medicine. The overall goal of our research is to investigate the molecular mechanisms that regulate progenitor cells in the developing kidney and to elucidate how developmental pathways in the kidney function in repair/regeneration after injury. Ongoing studies are focusing on understanding how transcription factors and their associated chromatin remodeling complexes regulate cell fate of nephron progenitor cells during formation of the kidney. A second area of emphasis is to investigate mechanisms and novel treatments of kidney fibrosis. We use genetically engineered mice, rodent models of kidney injury, genomics (ChIP-seq, bulk & single cell RNA-seq), primary cell culture of nephron progenitor cells and advanced imaging techniques.

Ongoing Studies:

  • Regulation of nephron progenitor cell fate in the developing kidney by the NuRD and SWI/SNF chromatin remodeling complexes
  • The role Sall1 and NuRD in formation of the loop of Henle epithelial segment of the mammalian nephron
  • Whole exome sequencing of parent-fetal/newborn trios and functional studies in zebrafish to identify novel gene variants that cause congenital anomalies of the kidney
  • Investigate a novel mouse model of focal segmental glomerulosclerosis due to deficiency of Mta2, a component of the NuRD complex
  • Determine the role of av intergins in promoting kidney fibrosis and test novel small molecule integrin inhibitors in pre-clinical studies in models of nephrotoxicity, ischemia and urinary tract obstruction

Required Qualifications

MD or PhD degree

Preferred Qualifications

  • Familiarity with the R statistical package for analysis of genomic data sets (ChIP-seq, RNA-seq)
  • Experience with cell culture techniques for stem/progenitor cells or organoids

Salary Range

Base pay commensurate with experience.

Department Summary

The Washington University Division of Nephrology (https://renal.wustl.edu) has been ranked top ten by US News & World Report every year since ratings began. The research environment is outstanding.

Benefits

This position is eligible for full-time benefits. Please visit our website at http://hr.wustl.edu to view a summary of benefits.

Applicant Special Instructions

To apply, please send CV to Dr. Michael Rauchman at mrauchma@wustl.edu.

EOE Statement

Washington University is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, age, sex, sexual orientation, gender identity or expression, national origin, genetic information, disability, or protected veteran status.

Job Title: Postdoctoral Research Associate - Nephrology - 41025

Job ID: 41025

Location: Medical School

Full/Part Time: Full-Time

Regular/Temporary: Regular