Washington University of St. Louis Bioinformaticist - Radiation Oncology - 42318 in St. Louis, Missouri

Job Type/Schedule

This position is full-time and works approximately 40 hours per week.

Department Name/Job Location

This position is in the Department of Radiation Oncology. This position is for the Medical School Campus.

Essential Functions

POSITION SUMMARY:

A Bioinformaticist position is available in the Radiation Oncology Cancer Biology Division working with Dr. Aadel Chaudhuri and Dr. Jin Zhang on Genomics data analysis and Bioinformatics programming. The candidate will play a critical role in setting up analysis pipelines and performing genomic analyses for multiple research projects in cancer biology, including circulating tumor DNA, digital cytometry, gene expression and gene fusion, machine learning/clustering using -omics data.

The position offers an excellent opportunity to conduct research in a supportive and stimulating environment, closely collaborating with computer scientists, biologists, and clinicians within the Department and other Institutes across the campus, including the Institute for Informatics.

PRIMARY DUTIES AND RESPONSIBILITIES:

  1. Setup analysis pipelines for cell-free DNA variant-calling and monitoring.
  2. Perform digital cytometry on publicly available data using CIBERSORT.
  3. Develop new analysis pipelines for variant-calling and monitoring.
  4. Gene expression analysis on all RNA species, including micro-RNA and long non-coding RNA, and other RNA species.
  5. Gene fusion analysis using RNA-seq and whole genome sequencing data.
  6. Conduct statistical analyses using genomic data and clinical features.
  7. Conduct/participate in machine learning/clustering analyses using -omics data.
  8. Effectively visualize data to convey critical findings to scientists, clinicians, and community members.
  9. Assist with grant preparation and reporting of methods, data and results.
  10. Help maintain, support, and document tools, code, and data sets.
  11. Train other researchers and users in the use of informatics tools we develop.

Required Qualifications

Bachelor’s degree in science or related field plus 4 years of experience required.

Preferred Qualifications

  • Ph.D. and experience of Bioinformatics software development and/or Bioinformatics data analysis.
  • Proficiency in scripting in Perl and Python.
  • Proficiency in a statistical programming language, such as R.
  • Familiar with objective-oriented programming using C/C++ or Java.
  • Familiar of variant calling (e.g. SNV, CNV, structural variation/gene fusion).
  • Highly motivated with excellent oral and written communication skills.
  • Experience with next-generation sequencing technologies including alignment, parsing, clipping and visualization tools.
  • Experience of statistical techniques for differential expression, gene set enrichment analysis, survival analysis.
  • Experience of machine learning/applied predictive modeling.
  • Experience with Git, Docker, and Cloud computing.

Salary Range

The hiring range for this position is $53,830 - $72,675 annually.

Pre-Employment Screening

Offers made for this position are contingent upon the successful completion of all required pre-employment screens, including a criminal background check, hair sample drug screen, and verification of required professional licenses, registrations, or certifications.

Department Summary

The Cancer Biology Division within the Department of Radiation Oncology consists of a core group of clinical, physics and computational science investigators who use both archived and prospectively collected tumor samples to ask fundamental questions about radiotherapy efficacy and cancer biology. The Bioinformatics Program works closely with clinicians to identify biomarkers that can be used to stratify patients and to identify patients for targeted therapies.

Benefits

This position is eligible for full-time benefits. Please visit our website at http://hr.wustl.edu to view a summary of benefits.

EOE Statement

Washington University is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, age, sex, sexual orientation, gender identity or expression, national origin, genetic information, disability, or protected veteran status.

Job Title: Bioinformaticist - Radiation Oncology - 42318

Job ID: 42318

Location: Medical School

Full/Part Time: Full-Time

Regular/Temporary: Regular